The Disease X Knowledge Base (DXKB) is an information system designed to support the discovery and development of immunogens for vaccine design, focusing on viral pathogens that may cause outbreaks of human disease. The DXKB contains curated data, custom visualizations, services, and artificial intelligence-based models intended to accelerate vaccine development.

The DXKB is hosted by researchers at the University of Chicago Consortium for Advanced Science and Engineering (CASE). The resource is freely available to the public.